However, no large clinical trials have been conducted yet.ĭr. Rapamycin is a well-known geroprotector, known to effectively slow aging in many species, including mice, and has been shown to delay age-related diseases in humans. To date the only known geroprotectors backed by promising clinical evidence of improved immune response to viral infection in the elderly are rapamycin and everolimus. There are multiple databases of geroprotectors and multiple strategies have been proposed to restore immune function in the elderly. There is no clinical evidence yet showing age reversal or improved immune function in the elderly, but efforts are underway to identify new geroprotectors using AI and human data. Furthermore, he believes that keeping older people healthy will re-ignite the economy and could potentially lead to unprecedented economic growth. He hopes that this research will yield insights that will help with COVID-19 and also help prevent age-associated diseases. Zhavoronkov is pursuing several strategies for drug discovery and repurposing using the latest advances in AI integrated into their battle-tested discovery platform. Zhavoronkov also proposes the use of inexpensive and minimally-invasive deep aging clocks to track the efficacy of these preventative geroprotective interventions and to stratify the patients by predicted severity of COVID-19.ĬOVID-19 infection rates in China Alex Zhavoronkov, PhDĭr. He has analyzed the prior clinical studies of everolimus (RAD001) in healthy elderly people, and previous evidence showing paradoxical immunopotentiation effects of rapamycin and proposed additional clinical trials for these molecules in the healthy elderly population. He proposes a strategy for repurposing known geroprotectors such as rapamycin, nicotinamide riboside, nicotinamide mononucleotide, metformin, and other drugs with a known safety profile for prevention of SARS-CoV-2 infection. Gerolavic comes from the Greek words geros (old man) and epilavís (harmful). Zhavoronkov suggests calling COVID-19 and other infections that are more harmful to the elderly gerolavic infections. I m Already Over Avatar Frontiers Of Pandora Like Far Cry 6 And Valhalla Before Itĭr.
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